Arsenal will be hoping to return to winning ways at the Emirates after following up their home defeat to Leicester with a win at Manchester United.
Thomas Partey, Gabriel and captain Pierre-Emerick Aubameyang are set to return after missing the Europa League win over Molde, while Bernd Leno will start.
Meanwhile, Aston Villa goalkeeper Emi Martinez returns to north London since his move in the summer.
The Argentine will be desperate to impress, particularly after conceding seven goals in his previous two outings.
Here’s everything you need to know before the match.
The fixture will kick-off at 7:15pm GMT at the Emirates Stadium.
The match will be televised on Sky Sports Box Office on a pay-per-view basis.
Mikel Arteta will welcome back Thomas Partey, Gabriel and captain Pierre-Emerick Aubameyang to the starting side after earning a rest for the Europa League. Pablo Mari and Gabriel Martinelli both remain out, while Reiss Nelson may not be fit in time for Sunday.
Dean Smith will be without Bertrand Traore, who suffered a groin injury in the home defeat to Southampton. The summer signing may return to action after the international break, alongside Tom Heaton. Wesley is out whilst Kortney Hause is a doubt for the trip to north London.
Arsenal: Leno, Holding, Gabriel, Tierney, Bellerin, Thomas, Elneny, Saka, Willian, Lacazette, Aubameyang
Aston Villa: Martinez, Cash, Konsa, Mings, Targett, McGinn, Luiz, Trezeguet, Barkley, Grealish, Watkins
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