The Reds are unbeaten in their last 67 league matches at home, but United possess the best away record in the division.
United have assumed top spot in the league after winning at Burnley on Tuesday, and they will be aiming to compound Liverpool’s poor run of form and move six points ahead in the table.
Here’s everything you need to know about the match:
The fixture will kick-off at 4:30pm GMT at Anfield.
The match is live on Sky Sports Premier League, with coverage starting from 4pm GMT.
Jurgen Klopp will assess Joel Matip prior to kick-off, with Nat Phillips and Rhys Williams waiting in the wings should the Cameroonian defender miss out. Naby Keita is still out with a muscle problem.
Ole Gunnar Solskjaer will use Saturday’s training session to see which players are fit to play, with Anthony Martial suffering a light hamstring issue against Burnley. Brandon Williams and Phil Jones are out.
Liverpool: Alisson, Alexander-Arnold, Fabinho, CB, Robertson, Henderson, Thiago, Wijnaldum, Salah, Firmino, Mane
Manchester United: de Gea, Wan-Bissaka, Lindelof, Maguire, Bailly, Shaw, McTominay, Pogba, Fernandes, Rashford, Cavani
This is the biggest Premier League fixture of the season so far, and it could go either way – one moment of brilliance by any of the individual superstars could win the game for their respective club. However, I think it could be quite scrappy as neither side wants to lose, and they settle for a draw. 1-1.